The near-infrared second region (NIR-II) organic photo diagnostic reagents have low tissue absorption, scattering and autofluorescence interference in living tissues, which can greatly improve the tissue penetration depth and resolution of fluorescence imaging. Thus NIR-II has broad biomedicine. application prospects. Among the reported NIR-II organic phototherapeutic, the commonly used molecular design strategies are based on expanding the π -conjugation length or enhancing the DA effect, but such molecules usually have poor water solubility, so the matrix encapsulation technology is used to form aggregates. Bulk nanoparticles (NPs) are a popular strategy to enhance their biocompatibility and water solubility. However, the NIR-II design strategy effectively regulating molecular stacking to construct NIR-II organic photo diagnostic reagents during the encapsulation process has not been reported in the literature. If it can be successfully applied, it will provide a more convenient and effective method for the construction of NIR-II organic photo diagnostic reagents. method.
Recently, the team of Academician Tang Benzhong of the Chinese University of Hong Kong (Shenzhen) and Professor Wang Jianguo of Inner Mongolia University published a research paper entitled "A Facile Structural Isomerization-Induced 3D Spatial DA Interlocked Network for Achieving NIR-II Phototheranostic Agents " on Angewandte Chemie International Edition. Through the in-depth study of the relationship between molecular structure and molecular packing, the author first proposed a strategy of structural isomerization-induced three-dimensional DA interlocking network (Fig. 1 ) to regulate molecular packing in the process of nano-encapsulation and design. A NIR-II organic phototherapeutic reagent with excellent photothermal stability, high photothermal conversion efficiency and reactive oxygen species generation ability.
Figure 1. The molecular design strategy of near-infrared second-region organic photo diagnostic molecule
Through the in-depth study of the relationship between molecular structure and molecular packing mode, the authors first proposed a strategy of structural isomerization-induced 3D spatial DA interlocking network, regulating the molecular packing mode in the process of nano-encapsulation. The photothermal stability, high photothermal conversion efficiency and reactive oxygen species generation ability of the near-infrared region II organic phototherapy reagent, and real-time near-infrared region II fluorescence imaging of mouse microcapillaries and tumor sites were reported. Injecting the photo-diagnostic organic molecule into tumor-bearing mice via the tail vein can perform photodynamic/photothermal synergistic therapy mediated by near-infrared region II fluorescence, showing good anticancer activity.
Figure 2. Photophysical and photodynamic performance tests
Figure 3. Photothermal performance test
Figure 4. Results of tumor treatment in tumor-bearing mice
This strategy of a three-dimensional DA interlocking network induced by structural isomerization provides a new idea for the design and development of NIR-II organic photo diagnostic molecules, which has potential biomedical application value in anticancer research.
Original link
A Facile Structural Isomerization-Induced 3D Spatial DA Interlocked Network for Achieving NIR-II Phototheranostic Agents. Lina Feng,Chunbin Li, Lingxiu Liu, Xin Chen, Guoyu Jiang,* Jianguo Wang,* and Ben Zhong Tang*
https://doi.org/10.1002/anie.202212673.
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